News from the Turner Lab
| September 15, 2023 | WashU night at the St. Louis Cardinals Baseball Game | Twitter Link |
| September 9, 2023 | Today is 9p Minus Day | Twitter Link |
| September 8, 2023 | Lab outing to the Endangered Wolf Center in St. Louis! | Twitter Link |
| September 2, 2023 | Our paper “Acorn: an R package for de novo variant analysis” is out now in BMC Bioinformatics! | BMC Bioinformatics Website |
| August 31, 2023 | Year 4 of the lab is complete. Starting year 5. | Twitter Link |
| August 24, 2023 | The lab is heading to #ASHG23 this year. Congratulations lab members on presentations; 3 posters, 1 talk! Check out our research on noncoding regions in autism, long-read sequencing, cell line characterization & 9p minus syndrome | Twitter Link |
| August 7 to 11, 2023 | Dr. Turner designed and taught the “Noncoding, Regulatory Regions in the Human Genome” section of the Immersion program for entering graduate students at WashU | Twitter Link |
| June 11, 2023 | Dr. Turner presents an invited talk “Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders” at the European Society of Human Genetics Conference in Glasgow, Scotland. | ESHG Link |
| June 7, 2023 | Our preprint “High Coverage Highly Accurate Long-Read Sequencing of a Mouse Neuronal Cell Line Using the PacBio Revio Sequencer” is now on bioRxiv. | bioRxiv Link |
| June 1, 2023 | We were highlighted in the “SFARI Sex Differences Collaborations gather to share their progress” article. | SFARI Link |
| May 25, 2023 | Today, we released several lab specific protocols on our website. | Website Link |
| May 11, 2023 | We celebrated Laura Metz Birthday today! | Twitter Link |
| May 3, 2023 | Dr. Turner presents an invited virtual talk “Precision Genomics in Neurodevelopmental Disorders” at the Mount Sinai Seaver Autism Center Seminar Series, | Twitter Link |
| April 28, 2023 | We celebrated Hillary Heins Birthday today! | Twitter Link |
| April 28, 2023 | A celebration of the end of an era. The very first person to join @TNTurnerLab was undergraduate Stephanie Sarkar. Today, we celebrated her time (4 years) in the lab and her upcoming graduation from Washington University in St. Louis. Congratulations Stephanie! | Twitter Link |
| April 27, 2023 | We celebrated our paper #6 “de novo variant calling identifies cancer mutation signatures in the 1000 Genomes Project” today! | Twitter Link |
| April 25, 2023 | Dr. Turner presents an invited talk “Precision Genomics in Neurodevelopmental Disorders” at the UT Southwestern O’Donnell Brain Institute. | Twitter Link |
| April 12, 2023 | Our preprint “acorn: an R package for de novo variant analysis” is now on bioRxiv. | bioRxiv Link |
| April 2, 2023 | Today, we released code and documentation for our HT-22 cell line project on our GitHub. | GitHub Link |
| March 30, 2023 | Today, we released ATAC-seq and Hi-C for the HT-22 cell line at our BioProject PRJNA938057. | NCBI Link |
| March 14, 2023 | Dr. Turner presents an invited talk “Precision Genomics in Neurodevelopmental Disorders” at the Rosamund Stone Zander Translational Neuroscience Center at Boston Children’s Hospital. | Twitter Link |
| March 5, 2023 | Today, we released additional datasets for the HT-22 cell line at our BioProject PRJNA938057. These include short-read Illumina whole-genome sequencing data, PolyA bulk RNAseq data, and long-read PacBio IsoSeq data. | NCBI Link |
| March 3, 2023 | Today, we released long-read PacBio whole-genome sequencing data for the HT-22 cell line at our BioProject PRJNA938057. | NCBI Link |
| February 17, 2023 | Dr. Turner presents an invited talk “Precision Genomics in Neurodevelopmental Disorders” at the Clemson University Center for Human Genetics & Department of Genetics and Biochemistry. | Twitter Link |
| January 28, 2023 | Our preprint “HAT: de novo variant calling for highly accurate short-read and long-read sequencing data” is now on bioRxiv. | bioRxiv Link |
| December 19, 2022 | Dr. Turner is a 40 under 40 rising star in Spectrum “Chronicle of a field retold: Autism science in profile” | Spectrum Link |
| December 9, 2022 | Today was our winter outing at Maggiano’s for Lunch and Bowling at Tropicana Lanes. | Twitter Link |
| November 10, 2022 | Dr. Turner gives an invited talk “Precision Genomics as a key component for the future of Precision Medicine” at the Cold Spring Harbor Laboratory Biological Data Science Meeting.
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CSHL Link |
| November 3, 2022 | NVIDIA highlights our recent work on de novo variant calling with GPUs in their NVIDIA Developer Technical Blog.
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NVIDIA Link |
| October 27, 2022 | Our lab releases a new R package (acorn) for assessing de novo variants. | GitHub Link |
| October 24, 2022 | Our lab releases a free version of HARE (our GPU-accelerated de novo variant caller) that utilizes the newly available free version of NVIDIA Parabricks.
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GitHub Link |
| October 3, 2022 | New staff members as of this week are Juana Manuel, Research Assistant and Hillary Heins, Research Specialist. Welcome to the @TNTurnerLab! | Twitter Link |
| September 28, 2022 | Evin Padhi defends his thesis and is the first Ph.D. graduate of the Turner Lab. | Website Link |
| August 18, 2022 | Dr. Turner is a co-author on new publication from SPARK “Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes” in Nature Genetics | Pubmed Link |
| August 14- 19, 2022 | Dr. Turner designed and taught the “Noncoding, Regulatory Regions in the Human Genome” section of the Immersion program for entering graduate students at WashU | Initial Twitter Link
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| July 1, 2022 | Dr. Turner received first R01 grant today from NIMH entitled “Noncoding mutations in neurodevelopmental disorders” | NIH Grant Website |
| June 30, 2022 | Dr. Turner and post-bac Titilope Akinwe are authors on a new paper from the Gutmann laboratory entitled “Neurofibromatosis-1 Gene Mutational Profiles Differ Between Syndromic Disease and Sporadic Cancers” published in the journal Neurology Genetics. | Journal Website |
| June 16, 2022 | Lunch celebration @MissionTacoSTL for Titilope Akinwe as she will be moving on to graduate school here at WashU and leaving our lab. Congratulations and Best Wishes! | Twitter Link |
| June 14, 2022 | Lab Outing to St. Louis Cardinals Baseball Game | Twitter Link |
| June 9, 2022 | The book “The Neuroscience of Autism” is out now! Check out the chapter on “Genetics and Genomics” Authors: Dr. Caitlin Hudac, Nicole Friedman, and Dr.Tychele Turner. | Book |
| May 31, 2022 | Dr. Turner is a co-author on a publication “Ancestry adjustment improves genome-wide estimates of regional intolerance” in the journal Genetics | Pubmed Link |
| May 14, 2022 | Dr. Turner presents an invited talk “Precision Genomics in Neurodevelopmental Disorders Empowered by the New Era of Long-Read Sequencing” at the International Society for Autism Research Conference in Austin, Texas | Meeting Website |
| May 11, 2022 | Dr. Turner presents an invited talk “Long-read sequencing as part of the pathway to precision genomics for precision medicine” at the PacBio Discoveries Roadshow in Houston, Texas | Meeting Website |
| May 10, 2022 | Dr. Turner presents an invited talk “Long-read sequencing as part of the pathway to precision genomics for precision medicine” at the PacBio Discoveries Roadshow in Chicago, Illinois | Meeting Website |
| May 2, 2022 | Dr. Turner presents an invited talk “Long-read sequencing as part of the pathway to precision genomics for precision medicine” at the PacBio Discoveries Roadshow in Columbus, Ohio | Meeting Website |
| April 20, 2022 | Eleanor Sams presents a poster entitled “Computational Modeling and Precision Genomics in CNV Disorders” at the Undergraduate Symposium | Poster Website |
| April 7, 2022 | Dr. Turner presents an invited talk “Long-Read Sequencing as Part of the Pathway to Precision Genomics for Precision Medicine” at the “Unlocking The Genome With Long-Read Sequencing In Genetic Disease Research” on-demand webinar | PacBio website |
| April 2, 2022 | Our lab paper “Germline mosaicism of a missense variant in KCNC2 in a multiplex family with autism and epilepsy characterized by long-read sequencing” is out now in the American Journal of Medical Genetics Part A | AJMG Website |
| April 1, 2022 | The “Textbook of Autism Spectrum Disorders, Second Edition” is out now! Check out the chapter on “Genetics and Genomics” Authors: Dr. Tychele Turner and Dr. Evan Eichler | Textbook Website |
| March 31, 2022 | Celebration of graduate school admissions of Eleanor Sams and Titilope Akinwe | Twitter Website |
| March 31, 2022 | Celebrated our Paper #4 today “From karyotypes to precision genomics in 9p deletion and duplication syndromes” | Twitter Website |
| March 8, 2022 | Dr. Turner presents invited talk “Precision Genomics in Neuropsychiatric and Neurodevelopmental Disorders Empowered by the New Era of Long-Read Sequencing” at the Molecular Psychiatry Association Meeting in Maui | MPA 2022 Website |
| February 11, 2022 | Dr. Turner is quoted in the Spectrum news article “Searching for the biology behind autism’s sex bias” | Spectrum News Website |
| February 3, 2022 | Dr. Turner presents invited talk “On a Pathway to Precision Genomics for Precision Medicine.” Washington University in St. Louis Vision Science Seminar Series. | Vision Science Website |
| January 12, 2022 | Dr. Turner is a co-author on paper “The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates” in Elife | Pubmed Link |
| January 8, 2022 | Final published version online now for lab paper “From Karyotypes to Precision Genomics in 9p Deletion and Duplication Syndromes” | HGG Advances Website |
| December 24, 2021 | Journal Pre-Proof online now for lab paper “From Karyotypes to Precision Genomics in 9p Deletion and Duplication Syndromes” | HGG Advances Website |
| December 10, 2021 | Winter Lab Outing to Union Station | |
| October 20, 2021 | Dr. Turner presents “Human Genomics in the New Era of Long-Read Sequencing” at the American Society of Human Genetics Conference! | ASHG Meeting Website |
| October 18 and 19, 2021 | Eleanor Sams, Evin Padhi, and Jeffrey Ng from the Turner Lab present at the American Society of Human Genetics Conference!
Eleanor Sams: Evin Padhi: Jeffrey Ng: |
ASHG Meeting Website |
| October 12, 2021 | Turner Lab publishes lab paper today. The paper entitled “ACES: Analysis of Conservation with an Extensive list of Species” was published in Bioinformatics! | Bioinformatics Article Link |
| October 6, 2021 | Dr. Turner is a co-author on a publication “Single-cell epigenomics reveals mechanisms of human cortical development” in Nature | Pubmed Link |
| September 27, 2021 | Stephanie Sarkar presents “Optimized de novo variant calling in family trios using GPUs” Poster Presentation at WashU Undergrad Research Week 2021! | WashU Website |
| September 27, 2021 | Eleanor Sams presents “Genomic Characterization of 9p Deletion and Duplication Syndromes” Video Poster Presentation at WashU Undergrad Research Week 2021! | WashU Website |
| September 16, 2021 | Dr. Turner is a co-author on a publication “Genetic counseling as preventive intervention: toward individual specification of transgenerational autism risk” in the Journal of Neurodevelopmental Disorders | Pubmed Link |
| July 23, 2021 | Dr. Turner is a co-author on a publication “Differences in the number of de novo mutations between individuals are due to small family-specific effects and stochasticity” in the journal Genome Research | Pubmed Link |
| July 21, 2021 | Dr. Turner is a co-author on a publication “Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7” in the journal BMC Biology | Pubmed Link |
| July 13, 2021 | Turner Lab publishes lab paper today! The paper entitled “Coding and noncoding variants in EBF3 are involved in HADDS and simplex autism” was published in Human Genomics. | Human Genomics Article Link |
| June 8, 2021 | Summer Lab Outing | |
| May 26, 2021 | Dr. Turner presents “Human Genomics in the New Era of Long-Read Sequencing” at the SMRT Leiden 2021 Young Investigator Virtual Conference. | PacBio Website |
| May 17, 2021 | WashU undergraduate student Ani Kesanapally joins the lab! | |
| May 4, 2021 | Dr. Turner presents “Identification and characterization of noncoding de novo variants in autism” at The International Society for Autism Research (INSAR) 2021 conference. | INSAR Website |
| April 20, 2021 | Dr. Turner presents “Application of Long-read Sequencing in Human Genetics” at LabRoots Genetics Virtual Week 2021 | LabRoots Website |
| April 19, 2021 | Titilope Akinwe presents a poster entitled “CLUMP Analysis of Missense Mutations in the Context of Neurodevelopmental Disorders” at the National Human Genome Research Institute Conference | Meeting Website |
| April 12, 2021 | Dr. Turner presents “Toward a One-Hour Genomic Workup” at NVIDIA GTC 2021 Conference | NVIDIA Website |
| April 6, 2021 | Eleanor Sams is a 2021 BioSURF Award Recipient | WUSTL Website |
| April 1, 2021 | Laura Metz joins the Turner lab as our lab manager! | Turner Lab Website |
| March 26, 2021 | Dr. Turner is an author on a new paper from the Gutmann laboratory entitled “Familial Lipomas Without Classic Neurofibromatosis-1 Caused by a Missense Germline NF1 Mutation” published in the journal Neurology Genetics. | PubMed Link |
| March 1, 2021 | At the AGBT 2021 conference Jeffrey Ng presented a poster on a fast workflow to call de novo variants using GPU. | AGBT Conference Link |
| March 1, 2021 | At the AGBT 2021 conference Zachary Payne presented a poster on a new reference genome for Chlamydomonas reinhardtii built using PacBio HiFi and Oxford Nanopore reads. | AGBT Conference Link |
| January 11, 2021 | Dr. Turner is co-corresponding author on a paper in Scientific Reports, “Thousands of high-quality sequencing samples fail to show meaningful correlation between 5S and 45S ribosomal DNA arrays in humans.” | Pubmed Link |
| January 7, 2021 | Dr. Turner is an author on a new paper from the laboratory of Dr. Gabe Haller. The paper “Rare and de novo coding variants in chromodomain genes in Chiari I malformation” was published in the American Journal of Human Genetics. | Pubmed Link |
| January 1, 2021 | Bioinformatic Research Analyst Elvisa Mehinovic joins the lab! | Turner Lab Website |
| December 1-3, 2020 | Undergraduate student Eleanor Sams presents a Video Poster Presentation “Predicting Autism Phenotypic Outcomes Based On Genotypic Information” at the WashU undergraduate symposium | WashU Undergraduate Symposium Website |
| November 30, 2020 | Graduate student Evin Padhi gives a platform talk entitled “Analysis of 10,000 genomes identifies two enhancers with a significant excess of de novo variants in autism.” at the American Society of Human Genetics 2020 meeting. | ASHG meeting website |
| October 19, 2020 | Dr. Turner gives an invited seminar at the New York Genome Center Neuropsychiatric Disease Working Group Evening Lecture | NYGC Website |
| September 14, 2020 | WashU graduate student Dan Western begins a rotation in the lab! | Turner Lab Website |
| September 8, 2020 | Titilope Akinwe joins the lab. Welcome! | Turner Lab Website |
| June 15, 2020 | Turner Lab publishes first lab paper today led by Jeffrey Ng and Eleanor Sams. The paper entitled “Precise Breakpoint Detection in a Patient With 9p- Syndrome” was published in the Pediatric Genetics special issue of Cold Spring Harbor Molecular Case Studies. | Cold Spring Harbor Molecular Case Studies Website |
| May 7, 2020 | Zachary Payne joins the lab and will be co-mentored by Dr. Susan Dutcher! | Turner Lab Website |
| May 7, 2020 | Dr. Turner joins the editorial board of Genome Research | Genome Research Link |
| April 13, 2020 | WashU graduate student Yoonhoo Chang begins a rotation in the Turner lab! | |
| March 25, 2020 | SPARK webinar by Dr. Tychele Turner, “Sex Bias and the Genetics of Autism” | SPARK link |
| March 23, 2020 | WashU graduate student Zachary Payne begins a rotation in the Turner and Dutcher labs! | |
| February 17, 2020 | Evin Padhi joins the lab as the first graduate student! | Turner Lab Website |
| February 6, 2020 | First lab lunch outing | Twitter Link |
| February 4, 2020 | The lab received the Human Genetics SMRT Grant today from Pacific Biosciences | Pacific Biosciences Link |
| January 17, 2020 | WashU graduate student Evin Padhi begins a rotation in the lab! | Turner Lab Website |
| January 13, 2020 | WashU undergaduate Eleanor Sams joins the lab! | Turner Lab Website |
| January 9, 2020 | Spectrum highlights our American Journal of Human Genetics paper | Spectrum Link |
| December 3, 2019 | The American Society of Human Genetics Inside AJHG chat about our recent paper | ASHG Link |
| December 1, 2019 | Bioinformatic Research Analyst Jeffrey Ng joins the lab! | Turner Lab Website |
| November 27, 2019 | Our paper entitled “Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders” is published in the American Journal of Human Genetics | AJHG Link |
| November 18, 2019 | Dr. Turner gives an invited seminar at the Washington University Intellectual and Developmental Disabilities Research Center | IDDRC Link |
| November 12, 2019 | WashU undergraduate Stephanie Sarkar joins the lab! | Turner Lab Website |
| October 16, 2019 | Dr. Turner and Dr. Sumantra Chatterjee (New York University) moderate their invited session at the American Society of Human Genetics meeting in Houston, Texas. Dr. Turner also presents recent work in the genetics of autism. | Twitter Link |
| September 24, 2019 | Our Early Career Investigator Commentary is online now in Biological Psychiatry | Biological Psychiatry Link |
| September 1, 2019 | Turner Lab Opens | Twitter Link |
| August 26, 2019 | The lab receives R00 funding from the National Institute of Mental Health. This is the next phase of Dr. Turner’s K99/R00 Pathway to Independence Award. | WashU Genetics Link |
| January 7, 2019 | Turner Lab to Open at Washington University School of Medicine in Fall 2019 | WashU Genetics Link |
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